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Schizophrenia Research Forum: Researcher Profile - Phil Corlett
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Researcher Profile - Phil Corlett

RESEARCHER INFORMATION
First Name:Phil
Last Name:Corlett
Title:Dr
Advanced Degrees:PhD
Affiliation:University of Cambridge
Department:Psychiatry
Street Address 1:Downing Site
Street Address 2:Downing Street
City:Cambridge
State/Province:Cambridgeshire
Zip/Postal Code:CB2 3EB
Country/Territory:United Kingdom
Phone:0441223764674
Email Address: 
Disclosure:
(view policy) 
Member reports no financial or other potential conflicts of interest. [Last Modified: 29 November 2007]
View all comments by Phil Corlett
Clinical Interests:
Psychology, Drug abuse, Schizophrenia
Research Focus:
Brain imaging, Chemistry/pharmacology, Genetics, Neuroanatomy/Systems Neuroscience, Phenomenology/diagnosis, Glutamatergic transmission
Work Sector(s):
University
Web Sites:
Personal: http://www.neuroscience.cam.ac.uk/directory/profile.php?prc28
Professional: www.cam.ac.uk
Lab: http://www-bmu.psychiatry.cam.ac.uk/
Reasearcher Bio
Delusions are odd beliefs. They accompany many psychiatric illnesses, notably schizophrenia. A major challenge is to understand delusions in terms of changes in brain function. I attempted to meet this challenge by investigating the neural basis of human associative learning and belief formation, relating these processes to the formation of delusional beliefs. My findings have shaped the development of a novel mechanistic model of delusion formation.

In future work I will refine this model by applying human molecular genetic techniques and targeted pharmacological manipulations to delineate the contribution of specific neurotransmitters, as well as intracellular processes to the formation of delusions. In so doing, a fuller explanation of these puzzling symptoms in terms of genes, brain function and psychological processes will become tractable.
Top Papers
1. Disrupted prediction error signal in delusions: evidence for an associative account of delusion formation

P Corlett, G Murray, G Honey, M Aitken, D Shanks, T Robbins, E Bullmore, A Dickinson, P Fletcher

Brain, In press, 2007

2. From prediction error to psychosis: ketamine as a pharmacological model of delusions

P Corlett, G Honey, P Fletcher

Journal of Psychopharmacology. 21(3):238-52 May 2007

3. Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: linking cognition, brain activity and psychosis

P Corlett, G Honey, M Aitken, A Dickinson, D Shanks, A Absalom, M Lee, E Pomarol-Clotet, P McKenna, T Robbins, E Bullmore and P Fletcher

Arch Gen Psychiat. 63(3): 611-21 June 2006

4. Prediction Error during Retrospective Revaluation of Causal Associations in Humans: fMRI Evidence in Favor of an Associative Model of Learning

P Corlett, M Aitken, A Dickinson, D Shanks, G Honey, R Honey, T Robbins, E Bullmore and P Fletcher

Neuron. 44(5):877 - 888 December 2004

5. Brain Imaging

P Fletcher, P Corlett

In: Psychosomatic Medicine. M Blumenfield and J Strain (Eds). Chapter 50. Lippincott Williams and Wilkins

6. Psychological effects of ketamine in healthy volunteers: a phenomenological study

E Pomarol-Clotet, G Honey, G Murray, P Corlett, A Absalom, M Lee, P McKenna, E Bullmore, P Fletcher

Br. J. Psychiatry. 189:173-9. August 2006

7. Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function

G Honey, E Pomarol-Clotet, P Corlett, R Honey, P McKenna, E Bullmore, P Fletcher

Brain. 128:2597-611 November 2005

8. The Effects of a Subpsychotic Dose of Ketamine on Recognition and Source Memory for Agency: Implications for Pharmacological Modelling of Core Symptoms of Schizophrenia.

G Honey, C O’Loughlin, D Turner, E Pomarol-Clotet, P Corlett, P Fletcher

Neuropsychopharmacology 31(2): 413-23 August 2006

9. Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens

J Dalley, K Laane, D Theobald, H Armstrong, P Corlett, Y Chudasama and T Robbins

PNAS. 102(17): 6189 – 6194 April 2005

10. On the Benefits of not Trying: Brain Activity and Connectivity Reflecting the Interactions of Explicit and Implicit Sequence Learning

P Fletcher, O Zafiris, C Frith, R Honey, P Corlett, K Zilles and G Fink

Cerebral Cortex. 15(7): 1002-15 July 2005



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