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Schizophrenia Research Forum: Researcher Profile - Eduardo Jesús Aguilar
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Researcher Profile - Eduardo Jesús Aguilar

First Name:Eduardo Jesús
Last Name:Aguilar
Affiliation:Hospital Clínico Universitario
Street Address 1:Avda. Blasco Ibáñez 17
Zip/Postal Code:46010
Email Address:
(view policy) 
Member reports no financial or other potential conflicts of interest. [Last Modified: 8 August 2006]
Clinical Interests:
Research Focus:
Neuroanatomy/Systems Neuroscience, Phenomenology/diagnosis, Clinical trials, Genetics
Work Sector(s):
Medical hospital
Reasearcher Bio
Hospital Universitario Virgen de la Arrixaca (Murcia, Spain): 1990-1994.
WPIC (Pittsburgh): 4 months in 1994.
Hospital Universitario de Canarias (Tenerife, Spain): 1995-1999.
Hospital de la Ribera (Alzira, Spain): 1999-2003.
Hospital de Sagunto (Sagunto, Spain): 2003-2004.
Hospital Clínico Universitario (Valencia, Spain): 2005-2006.
Top Papers
1. Aguilar EJ, Keshavan MS, Martinez-Quiles MD, Hernandez J, Gomez-Beneyto M, Schooler NR. Predictors of acute dystonia in first-episode psychotic patients. Am J Psychiatry. 1994 Dec;151(12):1819-21. PMID: 7977894.

2. Aguilar EJ, Haas G, Manzanera FJ, Hernandez J, Gracia R, Rodado MJ, Keshavan MS. Hopelessness and first-episode psychosis: a longitudinal study.Acta Psychiatr Scand. 1997 Jul;96(1):25-30. PMID: 9259220.

3. Gracia Marco R, Aguilar Garcia-Iturrospe EJ, Fernandez Lopez L, Cejas Mendez MR, Herreros Rodriguez O, Diaz Ramirez A, Hernandez Martinez J, Keshavan MS. Hypofrontality in schizophrenia: influence of normalization methods. Prog Neuropsychopharmacol Biol Psychiatry. 1997 Nov;21(8):1239-56. PMID: 9460089

4. Keshavan MS, Haas GL, Kahn CE, Aguilar E, Dick EL, Schooler NR, Sweeney JA, Pettegrew JW. Superior temporal gyrus and the course of early schizophrenia: progressive, static, or reversible?. J Psychiatr Res. 1998 May-Aug;32(3-4):161-7. PMID: 9793869

5. Aguilar EJ, Leal C, Acosta FJ, Cejas MR, Fernandez L, Gracia R. A psychopathological study of a group of schizophrenic patients after attempting suicide. Are there two different clinical subtypes?. Eur Psychiatry. 2003 Jun;18(4):190-2. PMID: 12814854.

6. Sanjuan J, Gonzalez JC, Aguilar EJ, Leal C, van Os J. Pleasurable auditory hallucinations. Acta Psychiatr Scand. 2004 Oct;110(4):273-8. PMID: 15352928.

7. Sanjuan J, Rivero O, Aguilar EJ, Gonzalez JC, Molto MD, de Frutos R, Lesch KP, Najera C. Serotonin transporter gene polymorphism (5-HTTLPR) and emotional response to auditory hallucinations in schizophrenia. Int J Neuropsychopharmacol. 2006 Feb;9(1):131-3. PMID: 15916716.

8. Sanjuan J, Aguilar EJ, de Frutos R. Time for a broad phenotype in schizophrenia?. Br J Psychiatry. 2006 Feb;188:190. PMID: 16449710.

9. Sanjuan J, Aguilar EJ, Olivares JM, Ros S, Montejo AL, Mayoral F, Gonzalez-Torres MA, Bousono M. Subjective perception of cognitive deficit in psychotic patients. J Nerv Ment Dis. 2006 Jan;194(1):58-60. PMID: 16462557.

10. Acosta FJ, Aguilar EJ, Cejas MR, Gracia R, Caballero-Hidalgo A, Siris SG. Are there subtypes of suicidal schizophrenia? A prospective study. Schizophr Res. 2006 Jul 12; in press, PMID: 16842974.
What are the top three papers (not yours) you have read recently?
1. Blasi G, Bertolino A. Imaging genomics and response to treatment with antipsychotics in schizophrenia. NeuroRx. 2006 Jan;3(1):117-30.

2. Mann JJ, Apter A, Bertolote J, et al. Suicide prevention strategies: a systematic review. JAMA. 2005 Oct 26;294(16):2064-74.

3. Keshavan MS, Roberts M, Wittmann D. Guidelines for clinical treatment of early course schizophrenia. Curr Psychiatry Rep. 2006 Jul;8(4):329-34.
If resources were not limited, what research projects would you pursue?
1.- Prospective study on suicide & first-episode psychotic patients by integrating psychopathology, response to psychotherapy, genetics and neuroimaging.

What is your leading hypothesis?
Neuropathological and psychopathological bases of emotion in schizophrenia, particularly related to positive symptoms and suicide: a genetic vulnerability interacts with social and psychological factors, can be traced through intermediate phenotypes and finally comes out as symptoms.
What piece of missing evidence would help prove it?
A neuroimaging study showing this interaction.

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