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Researcher Profile - Paul Patterson |
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| First Name: | Paul | | Last Name: | Patterson | | Title: | Professor | | Advanced Degrees: | PhD | | Affiliation: | California Institute of Technology | | Department: | Biology | | Street Address 1: | 216-76 | | City: | Pasadena | | State/Province: | CA | | Zip/Postal Code: | 91125 | Country/Territory: | U.S.A. | | Phone: | 626-395-6826 | | Fax: | 626-585-8743 | | Email Address: |  |
Disclosure:
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Member reports no financial or other potential conflicts of interest. [Last Modified: 20 October 2005]
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View all comments by Paul Patterson
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Autism spectrum disorders (pervasive developmental disorders), Depression, Neurodevelopmental disorders (e.g., 22q11 deletion syndromes), Schizophrenia
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Neuropathology, Epidemiology, Glia/myelin, Immunology, Neurodevelopment, DNA microrrays, Stem cells, Animal models, Molecular and Cell biology
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Shi, L, Fatemi, SH, Sidwell, RW and Patterson, PH (2003) A mouse model of mental illness: maternal influenza infection causes behavioral and pharmacological abnormalities in the offspring. J. Neurosci. 23: 297-302.
Patterson, PH (2004) Maternal infection causes altered behavior in the offspring. In “Neuropsychiatric Disorders and Infection”, SH Fatemi ed., Taylor & Francis, London, pp. 83-90.
Shi, L, Tu, N and Patterson, PH (2005) Maternal influenza infection is likely to alter fetal brain development indirectly: the virus is not detected in the fetus. Internl. J. Develop. Neurosci. 23: 299-305.
Patterson, PH (2005) Modeling features of autism in animals, In “Understanding Autism: From basic Neuroscience to Treatment”, Moldin, SO and Rubenstein, ,JLR, Eds., Taylor & Francis, Boca Raton, FL, in press. |
Brown, A.S., et al., Serologic evidence of prenatal influenza in the etiology of schizophrenia, Arch. Gen. Psychiatry, 61, 774, 2004
Meyer, U., Feldon, J., Schedlowski, M. and Yee, B.K., Towards an immuno-precipitated neurodevelopmental animal model of schizophrenia, Neurosci. Biobehav. Rev., 29, 913, 2005
Vargas, D.L., et al., Neuroglial activation and neuroinflammation in the brain of patients with autism, Ann. Neurol., 57, 67, 2005 |
Maternal infection interacts with genetic susceptibility to increase the risk for schizophrenia in the offspring. We hypothesize that infection-induced maternal cytokines mediate changes in fetal brain development, which leads to behavioral abnormalities and neuropathology in the offspring. |
In a mouse model of maternal influenza infection, we are perturbing cytokines in the maternal circulation and observing changes in the behavior of the offspring. |
The maternal cellular immune response may play a role. |
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