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Schizophrenia Research Forum: Researcher Profile - Andreas Meyer-Lindenberg
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Researcher Profile - Andreas Meyer-Lindenberg

RESEARCHER INFORMATION
First Name:Andreas
Last Name:Meyer-Lindenberg
Title:Investigator
Advanced Degrees:MD PhD
Affiliation:Central Institute of Mental Health
Country/Territory:Germany
Email Address: 
Disclosure:
(view policy) 
Member reports no financial or other potential conflicts of interest. [Last Modified: 20 October 2005]
View all comments by Andreas Meyer-Lindenberg
Clinical Interests:
Neurodevelopmental disorders (e.g., 22q11 deletion syndromes), Schizophrenia
Research Focus:
Bioinformatics/Statistics, Brain imaging, Genetics
Work Sector(s):
Government
Web Sites:
Professional: www.nimh.nih.gov
Lab: snp.nimh.nih.gov
Reasearcher Bio
Dr. Meyer-Lindenberg is Chief of the Unit for Systems Neuroscience in Psychiatry and Co-Director of the Imaging Core Facility of the Genes, Cognition and Psychosis program. A German national, he studied medicine at Bonn (Germany) and Cornell University and did residencies in psychiatry and psychotherapy in Giessen (Germany) and in neurology in Bonn. He received his M.D. in 1991 and his Ph.D. (Habilitation) in 1999. He is board certified in psychiatry, psychotherapy and neurology. He also holds a Master's degree in pure and applied mathematics from the University of Hagen (Germany).

Top Papers
Meyer-Lindenberg A, Olsen RK, Kohn PD, Holt JL, Egan MF, Weinberger DR, Berman KF: Regionally specific disturbance of dorsolateral prefrontal - hippocampal functional connectivity in schizophrenia. Arch Gen Psychiat, 2005 Apr;62(4):379-86.
Meyer-Lindenberg A, Kohn PD, Kolachana B, Kippenhan S, Mcinery-Leo A, Nussbaum RL, Weinberger DR, Berman KF: Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype. Nature Neuroscience, 2005 May;8(5):594-596.
Krieger S, Lis S, Cetin T, Gallhofer B, Meyer-Lindenberg A: Executive Function and cognitive sub-processes in first-episode, drug-naive schizophrenia: an analysis of n-back performance. American J Psychiatry, 2005 Jun;162(6):1206-8.
Pezawas L*, Meyer-Lindenberg A*, Drabant EM, Verchinski B, Mattay VS, Hariri AR, Kolachana B, Egan MF, Weinberger DR: 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nature Neuroscience, 2005 Jun;8(6):828-34. (*shared first authorship)
Meyer-Lindenberg A, Mervis CB, Sarpal D, Koch P, Steele S, Kohn P, Marenco S, Morris CA, Das S, Kippenhan S, Mattay VS, Weinberger DR, Berman KF: Functional, structural and metabolic abnormalities of the hippocampal formation in Williams syndrome. J Clin Investigation 2005, 115: 1888-1895.
Meyer-Lindenberg A, Hariri AR, Munoz KE, Morris CA, Mervis C, Mattay VS, Berman KF: Neural correlates of genetically abnormal social cognition in Williams syndrome. Nature Neuroscience, 2005 Aug;8(8):991-993.
Kippenhan S, Olsen R, Kohn PD, Mervis CB, Morris CA, Kohn PD, Meyer-Lindenberg A*, Berman KF*: Genetic Contributions to Human Gyrification: Sulcal Morphometry in Williams Syndrome. (*shared senior authorship) J Neurosci, 2005 25: 7840-7846.
Meyer-Lindenberg A, J.B. Poline, P. Kohn, J. Holt, M. Egan, D.R. Weinberger, K.F. Berman: Evidence for abnormal cortical functional connectivity during working memory in schizophrenia. American J Psychiatry, 158(2001), 1809-17.
Meyer-Lindenberg A, Miletich R, Kohn P, Esposito G, Carson R, Quarantelli M, Weinberger DR and Berman KF: Prefrontal Cortex Activity Predicts Exaggerated Striatal Dopaminergic Function in Schizophrenia. Nature Neuroscience (2002) 5:267-271.
Meyer-Lindenberg A, Ziemann U, Hajak G, Cohen L, Berman KF: Transitions between dynamical states of differing stability in the human brain. Proc Natl Acad Sci U S A 2002 99(17):10948-53
Meyer-Lindenberg A, Kohn P, Mervis CB, Olsen R, Kippenhan S, Morris CA, Berman KF: Neural basis of genetically determined visuospatial construction deficit in Williams syndrome. Neuron, 2004 43(5):623-31.
What are the top three papers (not yours) you have read recently?
Hammock EA, Young LJ. Microsatellite instability generates diversity in brain and sociobehavioral traits. Science. 2005 Jun 10;308(5728):1630-4.
Massimini M, Ferrarelli F, Huber R, Esser SK, Singh H, Tononi G. Breakdown of cortical effective connectivity during sleep. Science. 2005 Sep 30;309(5744):2228-32.
Khaitovich P, Hellmann I, Enard W, Nowick K, Leinweber M, Franz H, Weiss G, Lachmann M, Paabo S. Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees. Science. 2005 Sep 16;309(5742):1850-4.
If resources were not limited, what research projects would you pursue?
Epidemiologically valid longitudinal study of brain function and structure related to genetic variation and environmental influences.
What is your leading hypothesis?
Interacting genetic variation in multiple risk genes impacts on functional brain circuits important for functions such as working memory, episodic memory, regulation of emotion and social cognition, forming the mechanism translating genetic effects into risk for schizophrenia.
What piece of missing evidence would help prove it?
An exhaustive enumeration of risk genes for schizophrenia demonstated to converge functionally on a limited set of neural mechanisms in human brain in vivo.
What is your fallback position?
I don't think one will be necessary in the next two decades.



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