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Current Hypotheses

Updated 4 December 2012

Important Notice: Schizophrenia Research Forum does not provide medical advice nor promote any product or service. The contents are for informational purposes only and are not intended to substitute for professional medical advice, diagnosis or treatment. Always seek advice from a qualified physician or health care professional about any medical concern, and do not disregard professional medical advice because of anything you may read on this web site. The views of individuals quoted on this site are not necessarily those of the Schizophrenia Research Forum.

Here we list reviews and other materials discussing current hypotheses about causes, pathogenesis, phenomenology, and treatments of schizophrenia and related diseases. These texts will introduce readers to some of the questions that drive current research into schizophrenia, as well as questions that have yet to be addressed. We welcome suggestions for topics to cover—or, even better, proposals for hypothesis papers. For more informal treatments of ideas and hypotheses, please go to the Idea Lab. See also our General Information directory.

The Dopamine Hypothesis of SchizophreniaUpdated 4 December 2012
By Anissa Abi-Dargham

Glutamate From a Cortical PerspectivePosted 24 July 2008
By Daniel Javitt

Glutamate Hypothesis of SchizophreniaUpdated 23 June 2008; Posted 8 November 2005
By Bita Moghaddam

An Epigenetic Hypothesis for Schizophrenia PathophysiologyPosted 17 January 2008
By Dennis R. Grayson, Alessandro Guidotti, and Erminio Costa

Bad Brain Vibes: Disturbances of Inhibitory Neural Circuits and Gamma Oscillations in SchizophreniaPosted 27 October 2006
By Tsung-Ung W. Woo, Kevin Spencer, and Robert M. McCarley

Schizophrenia Risk and the Paternal Germ LinePosted 3 March 2006
By Dolores Malaspina

Do Chimpanzees Suffer from Schizophrenia?Posted 1 November 2005
By Tim Crow

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