Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
News
Research News
Conference News
Plain English
Forums
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
Interviews
Resources
What We Know
SchizophreniaGene
Animal Models
Drugs in Trials
Research Tools
Grants
Jobs
Conferences
Journals
Community Calendar
General Information
Community
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
Mission
History
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.
Online Discussions

Updated 5 February 2013 E-mail discussion
Printable version

Live Discussion: Taking Stock of Glutamate in Schizophrenia


Dan Javitt

Bita Moghaddam

Joseph Coyle

Adrienne Lahti

Handan Gunduz-Bruce

Lawrence Kegeles

Daniel Javitt, Bita Moghaddam, and Joseph Coyle, along with discussants Adrienne Lahti of the University of Alabama at Birmingham, Lawrence Kegeles of Columbia University, and Handan Gunduz-Bruce of Yale University, weighed in on the state of the idea that disturbed glutamate signaling contributes to the positive, negative, and cognitive symptoms of schizophrenia, and that retuning this system may offer some relief.

Many thanks to the Maryland Psychiatric Research Center and Oxford University Press, publishers of Schizophrenia Bulletin, for providing open access to the introductory article for this Webinar.

Javitt DC. Twenty-five years of glutamate in schizophrenia: Are we there yet? Schizophr Bull 2012 Sept; 38(5): 911-913. Abstract

0:57—Joe Coyle
17:00—Bita Moghaddam
30:56—Dan Javitt
46:50—Larry Kegeles
54:20—Adrienne Lahti
1:03:52—Handan Gundun-Bruce
1:13:00—Panel Discussion/Q&A

View Comments By:
Philip Seeman — Posted 17 January 2013
Philip Seeman — Posted 23 January 2013
Charles Stromeyer Jr. — Posted 4 February 2013
Sergey Serdyuk — Posted 8 February 2013
Philip Seeman — Posted 8 February 2013
Paul Morrison — Posted 14 May 2013


It’s been 25 years since glutamate emerged as a potential therapeutic strategy for schizophrenia, but how is the “great glutamate hope” faring these days? In the past year, some findings have strengthened the link between upended glutamate signaling involving N-methyl-D-aspartate (NMDA) receptors (see SRF related news story and SRF news story), but disappointing clinical trials (see SRF related news story and SRF news story) have emphasized the difficulties of translating preclinical findings to helping people with schizophrenia.

Based on a series of themed articles published in the September 2012 issue of Schizophrenia Bulletin, our discussion surveyed the history of the glutamate hypothesis of schizophrenia, including the initial observation of psychomimetic effects of the drug phencyclidine (PCP); the involvement of glutamate signaling in these, with NMDA receptor antagonists mimicking a constellation of schizophrenia-like symptoms; and the current standing of various glutamate-based therapies (see also SRF Current Hypotheses papers on the topic by Moghaddam and Javitt.

To prime the discussion, the following questions were considered. Please add a comment about them, or some other ideas related to glutamate in schizophrenia:

1. How to reconcile the preclinical evidence for glutamate in psychosis and other schizophrenia-like symptoms with the recent failed clinical trials of glutamate drugs?

2. Is there a way to firm up the relationship between NMDA receptor antagonism and schizophrenia symptoms in humans?

3. With recent studies associating cannabis or methamphetamine with psychosis in humans, does this warrant rethinking the usefulness of tracking down psychomimetic effects of any drug? Is psychosis too general a symptom?

4. What can be said for circuit specificity? Are all glutamate-using circuits affected in schizophrenia, or is there a subset involved?

5. How does NMDA receptor blockade lead to the schizophrenia-like symptoms? Ideas include underactive NMDA receptors, compensatory hyperactive glutamate release, or disrupted GABA signaling. How do these models fit together?


Comments on Online Discussion
Comment by:  Philip Seeman (Disclosure)
Submitted 16 January 2013 Posted 17 January 2013

While it is important to pursue several basic approaches...  Read more


View all comments by Philip Seeman

Comment by:  Philip Seeman (Disclosure)
Submitted 23 January 2013 Posted 23 January 2013

This is in reply to the excellent preliminary...  Read more


View all comments by Philip Seeman

Comment by:  Charles Stromeyer Jr.
Submitted 30 January 2013 Posted 4 February 2013

This new paper (  Read more


View all comments by Charles Stromeyer Jr.

Comment by:  Sergey Serdyuk
Submitted 6 February 2013 Posted 8 February 2013

As is known, all NMDA antagonists produce hyperactivity,...  Read more


View all comments by Sergey Serdyuk

Comment by:  Philip Seeman (Disclosure)
Submitted 5 February 2013 Posted 8 February 2013

The dopamine-like action of phencyclidine inhibits the...  Read more


View all comments by Philip Seeman

Comment by:  Paul Morrison
Submitted 11 May 2013 Posted 14 May 2013

Ketamine, a drug that has attracted the attention of...  Read more


View all comments by Paul Morrison
Submit a Comment on This Online Discussion
Make a comment on this live discussion. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Affiliation  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Password  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
 
Enter the code as it is shown below:
This code helps prevent automated registrations.

Please note: A member needs to be both registered and logged in to submit a comment.

Comment:

(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)

References:



SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Share/Bookmark
Live Discussion FAQs

Webinar: A Webinar is a seminar conducted remotely over the Web. Attendees view the slides through their Web browser and hear the presentations over their own telephones.

Registration: All participants are to register by clicking on the "Register for the Webinar" link.

Access: After you register, you will receive an e-mail with a link to the Webinar and a phone number.
New Schizophrenia Fact Sheet for Patients and Families

Latest BBRF Research Breakthroughs

Visit our Facebook page and our Blog.

Support the Brain & Behavior Research Foundation Today.

Research Participants
Collaborators
Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright