Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
Research News
Conference News
Plain English
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
What We Know
Animal Models
Drugs in Trials
Research Tools
Community Calendar
General Information
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.

Chen PL, Avramopoulos D, Lasseter VK, McGrath JA, Fallin MD, Liang KY, Nestadt G, Feng N, Steel G, Cutting AS, Wolyniec P, Pulver AE, Valle D. Fine mapping on chromosome 10q22-q23 implicates Neuregulin 3 in schizophrenia. Am J Hum Genet . 2009 Jan 1 ; 84(1):21-34. PubMed Abstract

Comments on Paper and Primary News
Primary News: Second Neuregulin Gene Supported In Schizophrenia Genetic Studies

Comment by:  Lin Mei
Submitted 30 January 2009 Posted 30 January 2009

Diagnosis of schizophrenia is psychiatric and based on patients’ self-reported experience or behavior. There are positive symptoms, negative symptoms, and cognitive deficits. Evidently, schizophrenia is a complex disease. No wonder current antipsychotics are effective for some, but not for all symptoms (in particular, negative symptoms and cognitive deficits). It would be no surprise if schizophrenia is classified or subclassified into different disorders in future when tools are available.

The beauty of the current study is to take advantage of detailed clinical information of schizophrenia patients and classify them to generate nine factors. Remarkably, a strong association was identified by using the delusion factor as quantitative trait phenotype. The finding itself identifies NRG3 as a candidate gene of "schizophrenia." In addition, it could represent a first step toward subclassification of schizophrenia for better diagnosis and treatment.

View all comments by Lin Mei

Submit a Comment on this Paper
Make a comment on this paper. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
Enter the code as it is shown below:
This code helps prevent automated registrations.

I recommend this paper

Please note: A member needs to be both registered and logged in to submit a comment.


(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)


SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright