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Annotation

Park YU, Jeong J, Lee H, Mun JY, Kim JH, Lee JS, Nguyen MD, Han SS, Suh PG, Park SK. Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin. Proc Natl Acad Sci U S A . 2010 Oct 12 ; 107(41):17785-90. PubMed Abstract

Comments on Paper and Primary News
Primary News: DISC1 Continued: Mitofilin as a Mitochondrial Mechanism

Comment by:  Christine Konradi
Submitted 2 November 2010 Posted 2 November 2010

Novel findings on the role of DISC1 and mitochondrial function
One of the most interesting genetic leads for schizophrenia and affective disorders is a balanced translocation on chromosome 1, leading to the disruption of DISC1 (disrupted-in-schizophrenia 1). The translocation is observed in a Scottish family with a history of major psychiatric disorders, and the linkage with psychiatric disorders has been thoroughly studied and confirmed (Blackwood et al., 2001). While the function of DISC1 is not entirely known, it has a strong connection with mitochondria. Animal models and studies in cell lines and cortical cultures showed that the protein localizes predominantly to mitochondria (Brandon et al., 2005; James et al., 2004; Morris et al., 2003). Expression of truncated DISC1 in cell lines, mimicking the translocation breakpoint in the Scottish pedigree, led to decreased mitochondrial...  Read more


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