Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
News
Research News
Conference News
Plain English
Forums
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
Interviews
Resources
What We Know
SchizophreniaGene
Animal Models
Drugs in Trials
Research Tools
Grants
Jobs
Conferences
Journals
Community Calendar
General Information
Community
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
Mission
History
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.
Annotation

Ho BC, Andreasen NC, Ziebell S, Pierson R, Magnotta V. Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia. Arch Gen Psychiatry . 2011 Feb ; 68(2):128-37. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Jeffrey Lieberman, SRF Advisor
Submitted 13 February 2011 Posted 14 February 2011
  I recommend this paper

The report by Ho et al. and commentary by Lewis illustrate the complexity of disentangling disease from treatment effects in evaluating the pathology of schizophrenia. This potentially confounded relationship has previously emerged in various lines of investigation such as evaluating the DA hypothesis of schizophrenia by measuring D2 receptor density in postmortem tissue.

Reductions in gray matter and increases in ventricular and subarachnoid space volume have been reported extensively in imaging and postmortem studies, including from before the introduction of antipsychotic drugs. Consequently, the neuropathology of schizophrenia, at least in part, is likely due to illness-related effects apart from pharmacologic treatment if not directly from disease pathophysiology. The study by Ho et al. suggests that the brain structural pathology is compounded, if not caused, by drug effects.

There are several limitations to the nature of the evidence that supports this conclusion. The first is the inherent, and potentially confounded, relationship between illness severity and...  Read more


View all comments by Jeffrey Lieberman
Submit a Comment on this Paper
Make a comment on this paper. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Affiliation  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Password  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
 
Enter the code as it is shown below:
This code helps prevent automated registrations.

I recommend this paper

Please note: A member needs to be both registered and logged in to submit a comment.

Comment:

(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)

References:


 
 
SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Share/Bookmark
Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright