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Annotation

Van Haren NE, Schnack HG, Cahn W, van den Heuvel MP, Lepage C, Collins L, Evans AC, Hulshoff Pol HE, Kahn RS. Changes in cortical thickness during the course of illness in schizophrenia. Arch Gen Psychiatry . 2011 Sep ; 68(9):871-80. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Karoly Mirnics, SRF Advisor
Submitted 16 September 2011 Posted 16 September 2011
  I recommend this paper

I am still struggling with the concept of cortical thinning in patients over time. I think this and previous studies have clearly demonstrated that there is a progressive cortical thinning in schizophrenia, which is also associated with poor clinical outcome. The higher cumulative intake of typical antipsychotics during the scan interval was associated with more pronounced cortical thinning in the current study, but this can be interpreted in multiple ways. Anyhow, I still have an unresolved issue in my mind: if cortical thinning is bad and impairs brain function, why is this progressive thinning not associated with much more pronounced clinical deterioration over the lifetime? Any comments?

View all comments by Karoly Mirnics


Primary News: Interpret With Care: Cortical Thinning in Schizophrenia

Comment by:  Cynthia Shannon Weickert, SRF Advisor
Submitted 4 January 2012 Posted 4 January 2012

Plump Enough
Thanks for your thought-provoking review of structural MRI changes in schizophrenia. I had a couple of quick comments.

You make the statement that, "Though cortical thickness itself is below the resolution of typical MRI, image analysis algorithms can now infer thickness across the entire cortical sheet as it winds its way throughout the brain." I thought sMRI gathers information for about 2 mm cubed or so. So maybe the point to make is that cortex thickness is not below the resolution, but the putative change in thickness is below the resolution. It would be interesting to know if the putative change in cortical thickness in schizophrenia could be better viewed with 3T or 7T scanners.

Also, I wonder how to interpret decreases in volume over five years that seem to be as much as 5 percent in some areas. How long could this continue to be progressive at this rate, and what would be the final cortical volume expected in the final decade of life? For example, if the DLPFC BA46 is about 3,500 microns thick, then a 5 percent loss/five years over 20...  Read more


View all comments by Cynthia Shannon Weickert
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