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Werbeloff N, Drukker M, Dohrenwend BP, Levav I, Yoffe R, van Os J, Davidson M, Weiser M. Self-reported attenuated psychotic symptoms as forerunners of severe mental disorders later in life. Arch Gen Psychiatry . 2012 May ; 69(5):467-75. PubMed Abstract

Comments on Paper and Primary News
Primary News: Attenuated Psychotic Symptoms: Risky, But Not Predictive of Psychosis

Comment by:  William Carpenter, SRF Advisor (Disclosure)
Submitted 8 March 2012 Posted 8 March 2012

Werbeloff et al. make a valuable contribution with an epidemiological cohort that permits estimates of self-reported attenuated psychosis-like experiences as a risk factor for a future psychotic disorder in the non-ill population. The possibility that attenuated psychosis syndrome would be included in DSM-5 has created an intense and interesting debate. Jim van Os and I, both members of the responsible DSM-5 Work Group, provided an update on the controversy last year (Carpenter and van Os, 2011), and I have offered a rebuttal to some of the objections elsewhere (Carpenter, 2011). As this is a work in progress, I will briefly state where we are, at the moment, in the DSM-5 process.

  • Criteria are developed and reliability data are presently being tested and evaluated. We know that experts with structured interviews have good reliability, but we need to determine whether non-expert clinicians have sufficient reliability to consider placing in the main text listing disorders...  Read more

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Primary News: Attenuated Psychotic Symptoms: Risky, But Not Predictive of Psychosis

Comment by:  William Carpenter, SRF Advisor (Disclosure)
Submitted 9 March 2012 Posted 9 March 2012

Editor's note: This is an addendum to Will Carpenter's previous comment above.

Jim van Os and colleagues now report on transition to psychosis from a non-clinical population sample. Transition rates are elevated for those with psychotic-like experiences, and persistence of these experiences increases risk for transition. Rates are substantially higher than the representative population without psychotic experiences, but much lower than clinical referral populations reported in studies to date.


Kaymaz N, Drukker M, Lieb R, Wittchen HU, Werbeloff N, Weiser M, Lataster T, van Os J. Do subthreshold psychotic experiences predict clinical outcomes in unselected non-help-seeking population-based samples? A systematic review and meta-analysis, enriched with new results. Psychol Med. 2012 Jan 20;1-15. Abstract

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