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Kano S, Colantuoni C, Han F, Zhou Z, Yuan Q, Wilson A, Takayanagi Y, Lee Y, Rapoport J, Eaton W, Cascella N, Ji H, Goldman D, Sawa A. Genome-wide profiling of multiple histone methylations in olfactory cells: further implications for cellular susceptibility to oxidative stress in schizophrenia. Mol Psychiatry . 2012 Aug 28 ; PubMed Abstract

Comments on Paper and Primary News
Comment by:  Kristen Brennand
Submitted 13 September 2012 Posted 13 September 2012

Olfactory neural cells have recently been developed as a novel cell-based model of psychiatric disorder. These primary neural cells can be established from nasal biopsies, making them the only source of live patient neural material that can be obtained directly from patients. Though olfactory neural progenitor cells (ONPs) cannot generate all the neural lineages specifically implicated in schizophrenia, they differentiate to mature electrophysiologically active neurons, making them an exciting platform to test for genetic neural defects present in schizophrenia (Benitez-King et al., 2011). ONPs from patients with schizophrenia and controls have altered cell cycle dynamics (Fan et al., 2012) as well as differences in gene expression of neurodevelopmental pathways associated with cell migration and axon guidance (Matigian et al., 2010).

In their letter to the editor at Molecular Psychiatry, Kano et al. compare H3K4me3 and H3K27me3...  Read more

View all comments by Kristen Brennand
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