Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
News
Research News
Conference News
Plain English
Forums
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
Interviews
Resources
What We Know
SchizophreniaGene
Animal Models
Drugs in Trials
Research Tools
Grants
Jobs
Conferences
Journals
Community Calendar
General Information
Community
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
Mission
History
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.
Annotation

Maccabe JH, Wicks S, Löfving S, David AS, Berndtsson Å, Gustafsson JE, Allebeck P, Dalman C. Decline in cognitive performance between ages 13 and 18 years and the risk for psychosis in adulthood: a Swedish longitudinal cohort study in males. JAMA Psychiatry . 2013 Mar ; 70(3):261-70. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Terry Goldberg
Submitted 12 February 2013 Posted 12 February 2013

Intellectual decline in schizophrenia has been an area of active investigation for well over two decades. In a twin paradigm, we reported evidence for intellectual decline in the schizophrenia proband, using both reading level and current IQ (Goldberg et al., 1990). In a later study we determined that intellectual decline is present in about 50 percent of patients and appears to be the modal presentation (Weickert et al., 2000).

In the current paper, MacCabe and colleagues attempt to pinpoint the timing of cognitive decline in a Swedish population-based study. They found strong evidence for decline in verbal ability in the 13-18 years of age period. Nevertheless, there are several unexpected features to the report.

First, though it is “population based,” the schizophrenia/schizoaffective N = 50 and bipolar N = 18 are rather small compared to many other studies in the area.

Second, the schizophrenia group has a relatively late onset (28 years at first hospitalization). This...  Read more


View all comments by Terry Goldberg

Comment by:  Timothea Toulopoulou
Submitted 22 February 2013 Posted 22 February 2013

Adolescence is a period of dramatic brain maturation and reorganization, and may also be a time of particular risk for pathophysiological processes underpinning neurodevelopmental models for psychiatric disorders such as schizophrenia. It, therefore, represents a particularly good period to examine for cognitive changes, as indices of that neurobiological risk, as they occur during that time of development. MacCabe’s excellent work complements numerous other streams of research that point in a similar direction, i.e., that a failure of normal verbal maturation during adolescence indicates later psychosis risk. However, without wanting to take anything away from the value of the study, we are left wondering whether we have been distracted by large samples, and association studies, for too long, perhaps confusing bigger with better? Epidemiological studies cannot tell us about the underlying neurobiology of the changes that occur during this period of development, and isn’t that where we should focus?

View all comments by Timothea Toulopoulou

Submit a Comment on this Paper
Make a comment on this paper. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Affiliation  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Password  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
 
Enter the code as it is shown below:
This code helps prevent automated registrations.

I recommend this paper

Please note: A member needs to be both registered and logged in to submit a comment.

Comment:

(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)

References:


 
 
SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Share/Bookmark
 
Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright