Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
Research News
Conference News
Plain English
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
What We Know
Animal Models
Drugs in Trials
Research Tools
Community Calendar
General Information
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.

Greenwood TA, Swerdlow NR, Gur RE, Cadenhead KS, Calkins ME, Dobie DJ, Freedman R, Green MF, Gur RC, Lazzeroni LC, Nuechterlein KH, Olincy A, Radant AD, Ray A, Schork NJ, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Sugar CA, Tsuang DW, Tsuang MT, Turetsky BI, Light GA, Braff DL. Genome-wide linkage analyses of 12 endophenotypes for schizophrenia from the consortium on the genetics of schizophrenia. Am J Psychiatry . 2013 May 1 ; 170(5):521-32. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Irving Gottesman, SRF Advisor
Submitted 27 March 2013 Posted 1 April 2013
  I recommend this paper

This is a landmark paper, one that complements the recent Lancet paper on the GWAS for five major psychiatric disorders (see SRF related news story). It would be of interest to extend the analyses, using the techniques of Glahn et al. (Glahn et al., 2012) for major affective disorders, that rank-orders the endophenotypes ("ERV") for their overall importance across numerous domains of data sources, including, in their case, imaging data.


Glahn DC, Curran JE, Winkler AM, Carless MA, Kent JW, Charlesworth JC, Johnson MP, Göring HH, Cole SA, Dyer TD, Moses EK, Olvera RL, Kochunov P, Duggirala R, Fox PT, Almasy L, Blangero J. High dimensional endophenotype ranking in the search for major depression risk genes. Biol Psychiatry . 2012 Jan 1 ; 71(1):6-14. Abstract

View all comments by Irving Gottesman

Comment by:  Timothea Toulopoulou
Submitted 17 April 2013 Posted 17 April 2013

Some of the very best schizophrenia scientists in the world are part of this consortium, and they are to be congratulated for making this work possible. I’d be interested to see if we can replicate these findings in our Wellcome Trust Case Control Consortium 2 (WTCCC2) collaboration, which uses similar endophenotypes. One comment: given the correlation between the endophenotypes, I would have been tempted to do proper multivariate analyses (SEM) to get the latent factor that captures the variance common to all endophenotypes before proceeding with linkage analyses. In this way, the variance specific to each endophenotype would be separate from the robust and reliable variance common to all endophenotypes.

View all comments by Timothea Toulopoulou

Submit a Comment on this Paper
Make a comment on this paper. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
Enter the code as it is shown below:
This code helps prevent automated registrations.

I recommend this paper

Please note: A member needs to be both registered and logged in to submit a comment.


(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)


SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright