Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
News
Research News
Conference News
Plain English
Forums
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
Interviews
Resources
What We Know
SchizophreniaGene
Animal Models
Drugs in Trials
Research Tools
Grants
Jobs
Conferences
Journals
Community Calendar
General Information
Community
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
Mission
History
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.
Annotation

Bernacer J, Corlett PR, Ramachandra P, McFarlane B, Turner DC, Clark L, Robbins TW, Fletcher PC, Murray GK. Methamphetamine-Induced Disruption of Frontostriatal Reward Learning Signals: Relation to Psychotic Symptoms. Am J Psychiatry . 2013 Jun 4 ; PubMed Abstract

Comments on Paper and Primary News
Comment by:  Lynn Selemon
Submitted 23 June 2013 Posted 23 June 2013

Bernacer et al. make an important contribution to the field by linking the basic neurobiologic mechanism underlying motivation and learning to psychosis in mental illness. It is particularly interesting that the potent D2 receptor antagonist amisulpride did not prevent the methamphetamine-induced disruption of incentive value signaling in the ventral prefrontal cortex. The authors discuss other possible pharmacologic sites, among them the D1 receptor, as the active site for methamphetamine in the cortex. I look forward to future studies by this group that elucidate the neurotransmitter(s) that may be involved.

View all comments by Lynn Selemon


Comment by:  J. Daniel Ragland
Submitted 25 June 2013 Posted 25 June 2013
  I recommend this paper

Phenomenologically, there can be striking similarities between acute psychotic symptoms in individuals with schizophrenia and individuals with acute methamphetamine abuse. There is also growing evidence that both conditions disrupt dopamine-rich frontostriatal brain networks, leading to similar changes in cognition, such as impaired performance on cognitive control tasks such as the Stroop (e.g., Salo et al., 2011). This current study by Bernacer and colleagues is one of the first to investigate the impact of methamphetamine on reward learning in healthy participants and uses fMRI, a methamphetamine challenge and a pharmacological intervention (the antipsychotic amisulpride) to get at putative monoaminergic mechanisms. fMRI results were convincing in linking reward prediction error to the ventral striatum and incentive value to the ventromedial prefrontal cortex. The disruptive effects of methamphetamine challenge on task performance and fMRI activation in candidate brain regions were also consistent with the notion that...  Read more


View all comments by J. Daniel Ragland
Submit a Comment on this Paper
Make a comment on this paper. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Affiliation  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Password  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
 
Enter the code as it is shown below:
This code helps prevent automated registrations.

I recommend this paper

Please note: A member needs to be both registered and logged in to submit a comment.

Comment:

(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)

References:


 
 
SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Share/Bookmark
 
Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright