Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
News
Research News
Conference News
Plain English
Forums
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
Interviews
Resources
What We Know
SchizophreniaGene
Animal Models
Drugs in Trials
Research Tools
Grants
Jobs
Conferences
Journals
Community Calendar
General Information
Community
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
Mission
History
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.
Annotation

Ripke S, O'Dushlaine C, Chambert K, Moran JL, Kähler AK, Akterin S, Bergen SE, Collins AL, Crowley JJ, Fromer M, Kim Y, Lee SH, Magnusson PK, Sanchez N, Stahl EA, Williams S, Wray NR, Xia K, Bettella F, Borglum AD, Bulik-Sullivan BK, Cormican P, Craddock N, de Leeuw C, Durmishi N, Gill M, Golimbet V, Hamshere ML, Holmans P, Hougaard DM, Kendler KS, Lin K, Morris DW, Mors O, Mortensen PB, Neale BM, O'Neill FA, Owen MJ, Milovancevic MP, Posthuma D, Powell J, Richards AL, Riley BP, Ruderfer D, Rujescu D, Sigurdsson E, Silagadze T, Smit AB, Stefansson H, Steinberg S, Suvisaari J, Tosato S, Verhage M, Walters JT, , Levinson DF, Gejman PV, Kendler KS, Laurent C, Mowry BJ, O'Donovan MC, Owen MJ, Pulver AE, Riley BP, Schwab SG, Wildenauer DB, Dudbridge F, Holmans P, Shi J, Albus M, Alexander M, Campion D, Cohen D, Dikeos D, Duan J, Eichhammer P, Godard S, Hansen M, Lerer FB, Liang KY, Maier W, Mallet J, Nertney DA, Nestadt G, Norton N, O'Neill FA, Papadimitriou GN, Ribble R, Sanders AR, Silverman JM, Walsh D, Williams NM, Wormley B, , Arranz MJ, Bakker S, Bender S, Bramon E, Collier D, Crespo-Facorro B, Hall J, Iyegbe C, Jablensky A, Kahn RS, Kalaydjieva L, Lawrie S, Lewis CM, Lin K, Linszen DH, Mata I, McIntosh A, Murray RM, Ophoff RA, Powell J, Rujescu D, van Os J, Walshe M, Weisbrod M, Wiersma D, , Donnelly P, Barroso I, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin AP, Deloukas P, Duncanson A, Jankowski J, Markus HS, Mathew CG, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Trembath RC, Viswanathan AC, Wood NW, Spencer CC, Band G, Bellenguez C, Freeman C, Hellenthal G, Giannoulatou E, Pirinen M, Pearson RD, Strange A, Su Z, Vukcevic D, Donnelly P, Langford C, Hunt SE, Edkins S, Gwilliam R, Blackburn H, Bumpstead SJ, Dronov S, Gillman M, Gray E, Hammond N, Jayakumar A, McCann OT, Liddle J, Potter SC, Ravindrarajah R, Ricketts M, Tashakkori-Ghanbaria A, Waller MJ, Weston P, Widaa S, Whittaker P, Barroso I, Deloukas P, Mathew CG, Blackwell JM, Brown MA, Corvin AP, McCarthy MI, Spencer CC, Bramon E, Corvin AP, O'Donovan MC, Stefansson K, Scolnick E, Purcell S, McCarroll SA, Sklar P, Hultman CM, Sullivan PF. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet . 2013 Oct ; 45(10):1150-9. PubMed Abstract

Comments on Paper and Primary News
Primary News: Bigger Schizophrenia GWAS Yields More Hits

Comment by:  Sven Cichon
Submitted 30 August 2013 Posted 30 August 2013

This paper is an important addition to the psychiatric genetics literature. One important message of it is that increasing the GWAS sample size in a complex neuropsychiatric phenotype such as schizophrenia identifies more common risk loci.

In the first-wave schizophrenia mega-analysis two years ago (Schizophrenia Psychiatric Genome-Wide Association Study Consortium, 2011), five risk loci at genomewide significance were detected, and it was speculated that more would follow with larger sample sizes. In fact, by performing a meta-analysis of a new Swedish schizophrenia sample (about 5,000 patients and 6,000 controls) and the first-wave PGC sample (about 9,000 patients and 12,000 controls) plus follow-up/replication in large, independent samples, the authors now find 22 genomic loci at genomewide significance. This is another important step forward in schizophrenia genetics.

It is reassuring (and important for the scientific community to know) that there is support for some of the previously reported loci. As expected, the...  Read more


View all comments by Sven Cichon

Primary News: Bigger Schizophrenia GWAS Yields More Hits

Comment by:  Ole A. Andreassen, SRF AdvisorMartin Tesli
Submitted 6 October 2013 Posted 7 October 2013
  I recommend this paper

The recent genomewide association study (GWAS) by Ripke and co-workers is a very important contribution to our knowledge of the genetic underpinnings of schizophrenia. By adding ~5,000 schizophrenia cases and ~6,000 healthy controls from Sweden to the Psychiatric Genomics Consortium (PGC) results from 2011 (PGC, 2011), the authors identified 22 gene loci (including 13 novel) at genomewide significance. These findings confirm that previous schizophrenia GWAS have been statistically underpowered, and that increasing the sample size is a successful approach to bridge the gap between the high heritability estimates in schizophrenia and low variance explained by currently identified genetic variants.

With increasing sample size, consistency is also enhanced. Reassuringly, of the 100 most significant SNPs in the Sweden/PGC meta-analysis, 90 percent had the same sign. Moreover, previously reported signals from immune-related genes in the MHC region on chromosome 6 were confirmed, as well as genes encoding calcium channel subunits,...  Read more


View all comments by Ole A. Andreassen
View all comments by Martin Tesli
Submit a Comment on this Paper
Make a comment on this paper. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Affiliation  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Password  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
 
Enter the code as it is shown below:
This code helps prevent automated registrations.

I recommend this paper

Please note: A member needs to be both registered and logged in to submit a comment.

Comment:

(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)

References:


 
 
SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Share/Bookmark
 
Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright