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Ernst A, Alkass K, Bernard S, Salehpour M, Perl S, Tisdale J, Possnert G, Druid H, Frisén J. Neurogenesis in the Striatum of the Adult Human Brain. Cell . 2014 Feb 19 ; PubMed Abstract

Comments on Paper and Primary News
Primary News: Fresh Neurons Seed the Human Striatum Throughout Life

Comment by:  Tom Burne
Submitted 5 March 2014 Posted 11 March 2014
  I recommend this paper

Disruption to the striatum has been implicated in schizophrenia, as well as Huntington’s disease. Postmortem studies have shown that schizophrenia may be associated with a deficit in cholinergic interneurons in the striatum, which may contribute to alterations in prefrontal cortex function in schizophrenia (Holt et al., 1999). These disruptions could reflect early neurodevelopmental insults. However, the recent findings from Ernst et al. suggest that a population of striatal interneurons turn over throughout life. Abnormalities in the ongoing repopulation of these cells could have far-reaching consequences for our understanding of the pathophysiology of schizophrenia and may suggest that the vulnerability to psychosis may extend well beyond periods of early brain development.

There is evidence indicating that some migrant groups have a significantly increased risk of schizophrenia (McGrath et al., 2004). Curiously, both first- and second-generation migrants have an increased risk...  Read more

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