Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
Research News
Conference News
Plain English
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
What We Know
Animal Models
Drugs in Trials
Research Tools
Community Calendar
General Information
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.

Camargo LM, Collura V, Rain JC, Mizuguchi K, Hermjakob H, Kerrien S, Bonnert TP, Whiting PJ, Brandon NJ. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Mol Psychiatry . 2007 Jan 1 ; 12(1):74-86. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Akira Sawa, SRF Advisor
Submitted 28 October 2006 Posted 28 October 2006

DISC1 is a promising risk factor for schizophrenia and mood disorders. DISC1 may also be involved in cognitive dysfunction associated with aging. Recent studies have suggested that DISC1 is multifunctional, with various isoforms (indeed, there are many more kinds of DISC1 isoforms than already published). An outstanding paper by Camargo, Brandon, and colleagues approached this fascinating, but complicated, molecule with a very unique approach. The authors conducted several sets of yeast two-hybrid screening with DISC1 and related proteins as baits, analyzed the experimental data with sophisticated bioinformatic methods, and generated a “DISC1 interactome map.”

The map is consistent with previous experimental reports. More importantly, it suggests a role for DISC1 in synaptic maturation and regulation. DISC1 and dysbindin, another promising risk factor for schizophrenia, share common protein-protein interactions, suggesting that these two risk factors may be in the same disease pathway. At the Society for Neuroscience meeting held in Atlanta last week, several groups...  Read more

View all comments by Akira Sawa
Submit a Comment on this Paper
Make a comment on this paper. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
Enter the code as it is shown below:
This code helps prevent automated registrations.

I recommend this paper

Please note: A member needs to be both registered and logged in to submit a comment.


(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)


SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright