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Greenwood TA, Swerdlow NR, Gur RE, Cadenhead KS, Calkins ME, Dobie DJ, Freedman R, Green MF, Gur RC, Lazzeroni LC, Nuechterlein KH, Olincy A, Radant AD, Ray A, Schork NJ, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Sugar CA, Tsuang DW, Tsuang MT, Turetsky BI, Light GA, Braff DL. Genome-wide linkage analyses of 12 endophenotypes for schizophrenia from the consortium on the genetics of schizophrenia. Am J Psychiatry. 2013 May 1 ; 170(5):521-32. Pubmed Abstract

Comments on News and Primary Papers


Primary Papers: Genome-wide linkage analyses of 12 endophenotypes for schizophrenia from the consortium on the genetics of schizophrenia.

Comment by:  Irving Gottesman
Submitted 27 March 2013
Posted 1 April 2013
  I recommend this paper

This is a landmark paper, one that complements the recent Lancet paper on the GWAS for five major psychiatric disorders (see SRF related news story). It would be of interest to extend the analyses, using the techniques of Glahn et al. (Glahn et al., 2012) for major affective disorders, that rank-orders the endophenotypes ("ERV") for their overall importance across numerous domains of data sources, including, in their case, imaging data.

References:

Glahn DC, Curran JE, Winkler AM, Carless MA, Kent JW, Charlesworth JC, Johnson MP, Göring HH, Cole SA, Dyer TD, Moses EK, Olvera RL, Kochunov P, Duggirala R, Fox PT, Almasy L, Blangero J. High dimensional endophenotype ranking in the search for major depression risk genes. Biol Psychiatry . 2012 Jan 1 ; 71(1):6-14. Abstract

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Primary Papers: Genome-wide linkage analyses of 12 endophenotypes for schizophrenia from the consortium on the genetics of schizophrenia.

Comment by:  Timothea Toulopoulou
Submitted 17 April 2013
Posted 17 April 2013

Some of the very best schizophrenia scientists in the world are part of this consortium, and they are to be congratulated for making this work possible. I’d be interested to see if we can replicate these findings in our Wellcome Trust Case Control Consortium 2 (WTCCC2) collaboration, which uses similar endophenotypes. One comment: given the correlation between the endophenotypes, I would have been tempted to do proper multivariate analyses (SEM) to get the latent factor that captures the variance common to all endophenotypes before proceeding with linkage analyses. In this way, the variance specific to each endophenotype would be separate from the robust and reliable variance common to all endophenotypes.

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