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Research News
 
News Briefs: RAISE Cost-Effectiveness and Clozapine in Treatment-Resistant Schizophrenia
9 February 2016. The benefits of comprehensive treatment for first-episode psychosis outweigh its higher costs, and a study suggests clozapine is no more effective than most other drugs...
 
Will Death in French Drug Trial Lead to Tighter Phase 1 Rules?
8 February 2016. This month saw one of the worst drug trial debacles in memory...
 
Purification of Adult Human Astrocytes Shows: They Are Unique
29 January 2016. Astrocytes make up almost half of a person's brain cells and are increasingly recognized to play a role in neurodegenerative disease...
 
 
 
 
Spotlight

Champions for the Mentally Ill Fall
Connie Lieber
Many people of means have good intentions to help those suffering, but few pour their hearts, souls, and bank accounts into it like Connie Lieber and Ted Stanley did. So it is sad that we have lost these two giants of mental illness philanthropy almost simultaneously, with Stanley passing away on January 4, and Lieber following on January 15. Connie was especially important to the Schizophrenia Research Forum, as editor
Hakon Heimer describes in his article about her, where you can also share your thoughts about what Connie meant to you in your research and work, and read remarks by the following commentators:
First Biological Fruits of the Schizophrenia GWAS
C4 (in green) at synapses
of primary human neurons
The risk genes for schizophrenia that lie hidden in the genetic swamp of the MHC region of chromosome 6 have eluded researchers since the days of linkage studies. But Steve McCarroll at Harvard/Broad Institute has fished out a likely culprit from GWAS results ... a version of the immune system molecule complement component 4 ... and,
together with Beth Stevens of Boston Children's Hospital, has linked it to cortical thinning in schizophrenia. Read the news story and offer your comments on what this might mean for future research. Image courtesy of Heather de Rivera (McCarroll lab)
New Date for Webinar on Social Cognition in Schizophrenia
Michael Green
Please join us for a special webinar Tuesday, February 23, 2016, at 2 p.m., US Eastern Time. Michael Green of the University of California, Los Angeles, and colleagues will present their recent paper in Nature Neuroscience: Social cognition in schizophrenia (Green et al., 2015). We will then hear from a panel of discussants: Melissa Green of the University of New South Wales in Sydney, Australia; Matthew Smith of Northwestern University in Chicago, Illinois; Stephan
Taylor of the University of Michigan in Ann Arbor; and Neeltje van Haren of University Medical Center Utrecht in the Netherlands.

You can add your preliminary thoughts by submitting a comment on the paper, and on comments already posted from:
De Novo Database Debuts
There is a new tool on the block for exploring mutations linked to schizophrenia and other developmental brain disorders. The DBD Gene Database, which was created by Christa Lese Martin and colleagues at the Autism and Developmental Medicine Institute in Lewisburg, Pennsylvania, integrates data about de novo mutations associated with six developmental brain disorders (Gonzalez-Mantilla et al., 2016). Candidate genes in the database are classified into tiers based on the reported number of loss-of-function variants (see press release).

The top hit for schizophrenia is neurexin, unsurprisingly. Other top candidates, including SYNGAP1 and ANKS1B, were reported in a 2014 Nature paper by Purcell and colleagues (see SRF related news story). SRF readers may want to take a spin through this visually appealing and well-annotated tool, and we hope that they and others will help the database grow in the coming years.
Welcome to the Schizophrenia Research Forum!
Welcome to the Schizophrenia Research Forum website—a virtual community for science about schizophrenia and related disorders. Our Mission is to help researchers in their quest for causes, improved treatments, and better understanding of schizophrenia. Read more about ways to browse the site.
 
What's New

Comments - Posted 8 February 2016
Read remarks by Ole A. Andreassen about Reininghaus U et al.
PAPER: Stress Sensitivity, Aberrant Salience, and Threat Anticipation in Early Psychosis: An Experience Sampling Study.
 
Comments - Posted 5 February 2016
Read remarks by Tada Mariko, Kiyoto Kasai about Rowland LM et al.
PAPER: Frontal Glutamate and ?-Aminobutyric Acid Levels and Their Associations With Mismatch Negativity and Digit Sequencing Task Performance in Schizophrenia.
 
Comments - Posted 4 February 2016
Read remarks by Robert Schwarcz about Sellgren CM et al.
PAPER: A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder.
 
Jobs - Posted 2 February 2016
Postdoctoral Opportunity in Human Genetics: Neurogenomics (Two-Year Contract): Laboratory of Neurogenomic Biomarkers, Centre for Integrative Biology, University of Trento, Italy.
 
Jobs - Posted 2 February 2016
Postdoctoral Opportunity in Human Genetics: Neurogenomics (One-Year Contract): Laboratory of Neurogenomic Biomarkers, Centre for Integrative Biology, University of Trento, Italy.
 
Comments - Posted 27 January 2016
Read remarks by Tom Insel
NEWS: The Schizophrenia Research Community Remembers Connie Lieber
February 10, 2016
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SIRS 2016
April 2-6, 2016
Firenze Fiera Congress Center, Florence, Italy


Registration is open! Pre-register by March 1, 2016, for discount.
We invite your comments and suggested edits to these facts about schizophrenia.
Compiled by Angus MacDonald, S. Charles Schulz, and the Minnesota Consensus Group.
Principles of Clinical Pharmacology: Developmental and Pediatric Pharmacology: Thursday, February 11, 2016, 6:30 p.m.

Loss of Skills and Onset Patterns in Neurodevelopment Disorders: Understanding the Neurobiological Mechanisms: Friday, February 19, 2016, 9:00 a.m.

A Molecular Rationale for the Unpredictable Nature of Behavior: Monday, February 22, 2016, 12:00 p.m.

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