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Research News
Common Pathways Found for Some Psychiatric Disorders
29 January 2015. Diverse genetic clues associated with three psychiatric disorders, including schizophrenia, point to a subset of key biological processes...
Elusive Hybrid Dopamine Receptor Stirs Controversy
15 January 2015. The hybrid dopamine receptor consisting of D1 and D2 subunits may not matter much to normal brain function...
SfN 2014—Redox Dysregulation in Schizophrenia
13 January 2015. Data suggest that redox dysregulation interacts with glutamatergic dysfunction and neuroinflammation to cause cognitive and affective symptoms of schizophrenia...

Elusive Hybrid Dopamine Receptor Stirs Controversy
D2 Receptor awaiting its D1 mate?
One would think that the illustrious dopamine D2 receptor would be understood in exhaustive detail at this point, but, in fact, there is much about it that remains to be determined. (As far as we know, there isn't even an experimentally derived crystal image, leaving us with the broad cartoon we show here.) A case in point is the D1/D2 receptor heteromer postulated by Susan George and colleagues at the University of Toronto. In a new paper online in Molecular
Psychiatry, Gregg Stanwood of Vanderbilt University and Jonathan Javitch of Columbia University suggest that it is illusory, at least in terms of physiological relevance to psychiatric disorders. Read Michele Solis' news story and George's initial reaction to the new paper. We invite you to join the discussion and let us know which argument persuades you and why.... Image: "Protein DRD2 PDB 1I15" by Pleiotrope. Own work. Licensed under Public Domain via Wikimedia Commons See comments by:
SfN Meeting Draws Researchers to Washington
The Lincoln Memorial
The Society for Neuroscience's annual meeting drew more than 30,000 to Washington, DC, from November 15 to 19. Over the next several weeks, keep an eye out for reports from the meeting by SRF reporter Allison Marin, beginning with a discussion of an issue that has created consternation throughout science: the
difficulty of replicating research, even the seminal studies in many fields.
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Welcome to the Schizophrenia Research Forum website—a virtual community for science about schizophrenia and related disorders. Our Mission is to help researchers in their quest for causes, improved treatments, and better understanding of schizophrenia. Read more about ways to browse the site.
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Jobs - Posted 29 January 2015
Research Associate: Imperial College London, Institute of Clinical Sciences, London, UK.
Conferences - Posted 29 January 2015
The Neuropsychopathology of Schizophrenia: 9-10 April 2015, University of Nebraska–Lincoln, Lincoln, Nebraska, U.S.A.
Comments - Posted 29 January 2015
Read remarks by Alexander B. Niculescu about The Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium. Psychiatric genome-wide association study analyses implicate neuronal et al.
NEWS: Common Pathways Found for Some Psychiatric Disorders
Comments - Posted 29 January 2015
Read remarks by Irving Gottesman about Birnbaum R et al.
PAPER: Investigation of the Prenatal Expression Patterns of 108 Schizophrenia-Associated Genetic Loci.
Comments - Posted 22 January 2015
Read remarks by Bryan Roth about Frederick AL et al.
NEWS: Elusive Hybrid Dopamine Receptor Stirs Controversy
Comments - Posted 20 January 2015
Read remarks by Richard Mailman about Frederick AL et al.
NEWS: Elusive Hybrid Dopamine Receptor Stirs Controversy
January 30, 2015
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15th International Congress on Schizophrenia Research

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An up-to-date collection of all published genetic association studies.
A community resource created by Jim Koenig, University of Maryland.
We invite your comments and suggested edits to these facts about schizophrenia.
Compiled by Angus MacDonald, S. Charles Schulz, and the Minnesota Consensus Group.
Replication in the Vicinity of Absolute Blocks to Replication: Tuesday, January 20, 2015, 12:30 p.m.

National Advisory Neurological Disorders and Stroke Council Meeting—January 2015: Thursday, January 29, 2015, 8:00 a.m.

The Generation of Cortical interneuron Diversity: Both Nurture and Nature: Monday, February 02, 2015, 12:00 p.m.

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